Healthy skin can be elusive in menopause due to declining estrogen levels and lower collagen production. It doesn’t mean you have to settle but it might be time for a change and better understanding of how to care for it.
If you deal with crepey skin, thinning skin, more visible lines and wrinkles, this is for you. Keep your healthy skin at every age.
My Guest:
OneSkin is founded and led by an all-woman team of PhD-level scientists, OneSkin is transforming the way we think about aging, starting with the body’s largest organ, the skin.Their proprietary OS-01 peptide is the first ingredient to reverse skin’s biological age by targeting cellular senescence, a key driver of aging. By targeting cellular senescence, the OS-01 peptide switches off the damaged cells that contribute to lines, wrinkles, and sagging skin. The result? Skin that looks and behaves younger. Their products are designed for both young and mature skin–because it’s never too early or too late to invest in your skin health! They create next level skin care.
The Science Behind Healthy Skin and Aging Gracefully
Questions We Answer in This Episode:
- [00:05:16] – Let’s start with the origin story—how did OneSkin come to be?
- [00:09:24] – Your team developed OS-01, the first peptide proven to reduce cellular senescence. Can you explain how this peptide works at the cellular level?
- [00:12:30] – How long before we actually see change?
- [00:14:44] – Why is lip skin more vulnerable than regular skin? What happens to lips with age?
- [00:17:51] – What is peptide?
- [00:20:00] – Let’s talk about skin in perimenopause and menopause—what’s actually happening hormonally that affects our skin so dramatically?
- [00:22:58] – For women who do HRT—do they get back some of that collagen production or firmness?
- [00:24:55] – If someone uses products and then stops, do the benefits fade when they stop using it?
- [00:25:57] – What would you say is a minimal, effective skincare routine for morning and night?
- [00:27:58] – What is your recommended exfoliating routine? Can we overdo that?
- [00:30:00] – What are some of your personal habits for healthy skin?
- [00:31:18] – What do you wish more women knew about their skin in midlife and beyond?
- [00:33:01] – What excited you most about the future of skincare and longevity?
Skincare That Works — Healthy Skin Is More Than Skin Deep
What Is Cellular Senescence (aka “Zombie Cells”)
- Cellular senescence: when damaged cells stop dividing and secrete inflammation.
- These “toxic” cells accelerate aging, break down collagen, and thin the skin barrier.
OneSkin’s OS-01 Peptide
- Peptides as “messenger molecules” that signal your cells to act younger.
- OneSkin screened 900+ molecules proven to make skin biologically younger.
- Helps reduce inflammation, boosts collagen restoration, clear senescent cells, and restore a healthy cellular environment.
How Fast Can You See Results?
- Immediate benefits: smoother, more hydrated skin.
- Long-term changes: firmer texture, fewer fine lines, improved glow within 1–3 months.
- Results accumulate over time—studies show improvements even after one year.
Lip Health: The Forgotten Area of Aging
- Lips lose volume and moisture faster than facial skin.
- OneSkin’s SPF and Night Lip Treatments, showing 100% improvement in fine lines after four weeks.
Skincare Routines That Work for Busy Women
- Gentle cleanser at night.
- Hydration + SPF in the morning.
- OneSkin’s peptide moisturizers deliver actives and hydration (no need for multiple serums).
- Over-exfoliation can damage the skin’s protective barrier.
Menopause and Skin Aging: The Collagen Crash
- Estrogen loss during menopause accelerates dryness, fine lines, and loss of firmness.
- Senescent cells and hormonal changes together create a “perfect storm” for aging skin.
The Lifestyle Habits That Show on Your Skin
- “Your skin is a mirror of your overall health.”
- Hydration, sleep, good nutrition, and exercise (yes, lifting weights!) are non-negotiables.
Connect with Alessandra:
- Interested in trying OneSkin?
Visit http://oneskin.co/FLIPPING50 and use code FLIPPING50 for 15% off your first purchase. - Instagram – @oneskin.co
- LinkedIn – One Skin
Other Episodes You Might Like:
- Previous Episode – Bone Density Updates for Women Over 50
- Next Episode – Exercise Recovery After 40: Connective Tissue in Menopause
- More Like This – Unlocking the Secrets to Skin Longevity | A Solution for Crepey Skin
Resources:
- Keep your skin healthy, strong and resilient as you age with OneSkin.
Visit http://oneskin.co/FLIPPING50 and use code FLIPPING50 for 15% off your first purchase. - Don’t know where to start? Book your Discovery Call with Debra. Leave this session with insight into exactly what to do right now to make small changes, smart decisions about your exercise time and energy.
- Are you burning belly fat or burning out? Get the Menopause Fitness Guide to High-Intensity Interval Training to help you lose more fat and stay on track!
